介绍
原位肿瘤模型是将肿瘤细胞系或患者来源的异种移植物，，原位移植到小鼠对应的原发器官中构建而成。。这种临床前研究方法能让肿瘤在具有生理相关性的微环境中生长和转移，，，进而实现对肿瘤 - 宿主相互作用、、免疫应答及治疗效能的精准评估。。与皮下异种移植模型相比，，，，原位肿瘤模型更能准确重现人类癌症中观察到的疾病进展过程和转移模式，，使其成为肿瘤学及免疫肿瘤学药物研发中极具价值的工具。。
体内光学成像技术
IVIS Spectrum 体内成像系统
Lumina LT Inst，，，，Series III
Micro-CT
NEMO II
这些成像平台能够在原位肿瘤模型中实时可视化肿瘤的生长与转移，，，，从而助力在体环境下对治疗效果进行精准评估。。。
原位和转移模型总结
聚力小事网络的原位肿瘤模型与转移模型经专门设计，，，，能够在体重现人类癌症的进展过程，，，且具有极高的转化相关性。。。。通过将肿瘤细胞原位移植到原发组织中，，这些在体模型可在生理条件下忠实模拟肿瘤的生长、、、侵袭及远处转移过程。。。。它们是肿瘤药物研发中评估抗肿瘤疗效、、、免疫应答及联合治疗策略的核心工具。。。。在先进在体成像技术的支持下，，我们的原位肿瘤模型可提供有关肿瘤负荷、、、、转移扩散及治疗结局的定量性、、、动态化洞察 —— 为您的研发管线提供更具预测价值的决策依据。。。
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| 4T1 |
Balb/c mice |
Mammary pad |
Orthotopic |
|
| MDA-MB-231 |
B-NDG mice |
Mammary pad |
Orthotopic |
|
| EO771 |
C57BL/6 mice |
Mammary pad |
Orthotopic |
|
| BT-474 |
B-NDG mice |
Mammary pad |
Orthotopic |
|
| DU4475 |
B-NDG B2M KO mice |
Mammary pad |
Orthotopic |
|
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-luc Hep 3B plus |
B-NDG mice |
Left hepatic parenchyma |
Orthotopic |
Yes (Small molecule, mRNA) |
| B-Tg(Luc-EGFP) Hep G2 |
B-NDG mice |
Left hepatic parenchyma |
Orthotopic |
Yes (ADC drug) |
| B-Luc PD-L1 MC38 |
C57BL/6 mice |
Spleen injection |
Liver metastasis |
|
| B-CMV-Luc H22 |
Balb/c mice |
Spleen injection |
Liver metastasis |
|
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-Tg(Luc) LNCap clone FGC |
B-NDG mice |
Ventral prostate |
Orthotopic |
Yes |
| B-Tg(Luc) PC-3 |
B-NDG mice |
Ventral prostate |
Orthotopic |
Yes |
| B-Tg(Luc) PC-3 |
B-NDG mice |
Intra-tibia |
Bone metastasis |
|
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-Luc MB49 |
C57BL/6N mice |
Bladder |
Orthotopic |
|
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-Tg(Luc) A549 |
B-NDG mice |
Tail vein |
Pulmonary aggregation |
|
| B-Luc LLC1 |
C57BL/6 mice |
Tail vein / lung puncture |
Pulmonary aggregation |
|
| B-luc LLC1 |
C57BL/6 Mice |
Tail artery |
Bone metastasis |
|
| B-luc LLC1 |
C57BL/6 Mice |
Intra-tibia |
Bone metastasis |
|
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-Luc GL261 |
C57BL/6 mice/B-hTFR1 |
Right caudate nucleus |
Orthotopic |
|
| B-Tg(CAG-Luc) U-87 MG |
B-NDG mice/B-NDG il15 mice |
Right caudate nucleus |
Orthotopic |
Yes |
| B-Tg(CAG-Luc) U-87 MG |
B-hTFR1/Rag2 KO mice |
Right caudate nucleus |
Orthotopic |
Yes |
| B-Tg(CAG-Luc) U-87 MG |
B-hTFR1 mice (2.5Gyx2) |
Right caudate nucleus |
Orthotopic |
Yes |
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-luc B16-F10 |
C57BL/6 mice |
Tail vein |
Pulmonary aggregation |
|
| B-Tg(CAG-Luc-EGFP) A375 |
B-NDG mice |
Intradermal |
Orthotopic |
|
| B-CMV-Luc A-431 |
B-NDG mice |
Intradermal |
Orthotopic |
|
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-CMV-Luc SNU-5 |
B-NDG mice |
Gastric wall |
Orthotopic |
|
